Base Pairs

by Cold Spring Harbor Laboratory

Base Pairs
  • Language: eng
  • Episodes: 19
  • Last: 15 Mar 2018
Cold Spring Harbor Laboratory's first fully-produced podcast series! Base Pairs ​tells​ stories that ​convey​ the power of genetic information — past and present.

Episodes (19)

  • 14 - The Cancer Answer That Wasn't
    14 - The Cancer Answer That Wasn't
    Play
    Published: 15 Mar 2018 Duration: 29:37
    We look at the "reproducibility crisis" in science, and dive into a case in which cancer researchers discovered something completely unexpected while experimenting with a supposed drug target.
    We look at the "reproducibility crisis" in science, and dive into a case in which cancer researchers discovered something completely unexpected while experimenting with a supposed drug target.

  • 13 – A Lesson in Class
    13 – A Lesson in Class
    Play
    Published: 8 Dec 2017 Duration: 21:55
    No, we're not talking about high society or your biology class! In this episode, we share three distinct stories about classification in the life sciences and how genetic information is changing how we define important categories.
    No, we're not talking about high society or your biology class! In this episode, we share three distinct stories about classification in the life sciences and how genetic information is changing how we define important categories.

  • 12.5 - Big Decisions
    12.5 - Big Decisions
    Play
    Published: 15 Nov 2017 Duration: 13:58
    Who will use CRISPR to alter their child's DNA? Who gets to decide which traits are desirable? Following up on our last episode, "Good Genes, Bad Science," we hear from David Micklos, executive director at CSHL’s DNA Learning Center, and Mi... Read more →
    Who will use CRISPR to alter their child's DNA? Who gets to decide which traits are desirable? Following up on our last episode, "Good Genes, Bad Science," we hear from David Micklos, executive director at CSHL’s DNA Learning Center, and Mi... Read more →

  • 12 - Good Genes, Bad Science
    12 - Good Genes, Bad Science
    Play
    Published: 13 Oct 2017 Duration: 27:07
    In the early 1900s, American science took a wrong turn toward eugenics. In this episode, we talk with experts in both science and history about what we can learn from this dark period in today’s age of unprecedented control over the genome.
    In the early 1900s, American science took a wrong turn toward eugenics. In this episode, we talk with experts in both science and history about what we can learn from this dark period in today’s age of unprecedented control over the genome.

  • 11.5 - What Silicon Valley and Biology Research Share
    11.5 - What Silicon Valley and Biology Research Share
    Play
    Published: 15 Sep 2017 Duration: 10:42
    A few favorite moments from our talk with theoretical physicist and quantitative biologist, Associate Professor Gurinder "Mickey" Atwal, that touch on topics ranging from his stint in medical school to the job market in the age of big data ... Read more →
    A few favorite moments from our talk with theoretical physicist and quantitative biologist, Associate Professor Gurinder "Mickey" Atwal, that touch on topics ranging from his stint in medical school to the job market in the age of big data ... Read more →

  • 11 – Biology, Behind the Screens
    11 – Biology, Behind the Screens
    Play
    Published: 14 Aug 2017 Duration: 21:57
    A "behind the screens" look at how biology is addressing its "most wonderful problem" – too much data. Associate Professor Gurinder S. "Mickey" Atwal joins us to explain the essential enigma that is quantitative biology.
    A "behind the screens" look at how biology is addressing its "most wonderful problem" – too much data. Associate Professor Gurinder S. "Mickey" Atwal joins us to explain the essential enigma that is quantitative biology.

  • 10.5 – Tomato Baby and its Family
    10.5 – Tomato Baby and its Family
    Play
    Published: 14 Jul 2017 Duration: 10:08
    Plant scientist Zachary Lippman tells stories from the field of bizarre tomatoes, intensely hot peppers, and giant pumpkins in this latest "chat" episode of Base Pairs. Hear more from Zack in episode 10 – CRISPR vs Climate Change.
    Plant scientist Zachary Lippman tells stories from the field of bizarre tomatoes, intensely hot peppers, and giant pumpkins in this latest "chat" episode of Base Pairs. Hear more from Zack in episode 10 – CRISPR vs Climate Change.

  • 10 – CRISPR vs Climate Change
    10 – CRISPR vs Climate Change
    Play
    Published: 14 Jun 2017 Duration: 24:40
    Much of the hype around the genome editing tool known as CRISPR focuses on its potential to cure genetic diseases. But our bodies need more than a healthy genome to survive and thrive—they also need food, and that’s where we may see CRISPR’... Read more →
    Much of the hype around the genome editing tool known as CRISPR focuses on its potential to cure genetic diseases. But our bodies need more than a healthy genome to survive and thrive—they also need food, and that’s where we may see CRISPR’... Read more →

  • 9.5 – Redefining Biologists, Redefining Genes
    9.5 – Redefining Biologists, Redefining Genes
    Play
    Published: 15 May 2017 Duration: 11:02
    Set aside your notions of how biologists are born, or what the word “gene” means as you listen to our first chat episode. We talk with Assistant Professor Molly Hammell, a genome biologist who started out as an astrophysicist. She tells us ... Read more →
    Set aside your notions of how biologists are born, or what the word “gene” means as you listen to our first chat episode. We talk with Assistant Professor Molly Hammell, a genome biologist who started out as an astrophysicist. She tells us ... Read more →

  • 9 – Dark Matter of the Genome (part 2)
    9 – Dark Matter of the Genome (part 2)
    Play
    Published: 14 Apr 2017 Duration: 25:17
    One scientist’s junk is apparently everyone’s treasure! They just haven’t realized it yet. . . In this episode of Base Pairs, we question the mythos that is “junk DNA” and explore how and why scientists are becoming enthralled by the myste... Read more →
    One scientist’s junk is apparently everyone’s treasure! They just haven’t realized it yet. . . In this episode of Base Pairs, we question the mythos that is “junk DNA” and explore how and why scientists are becoming enthralled by the myste... Read more →

  • 8 – Dark Matter of the Genome (part 1)
    8 – Dark Matter of the Genome (part 1)
    Play
    Published: 14 Mar 2017 Duration: 23:55
    Could “genome” be a misnomer? The name implies that our genetic information is mainly genes, yet when the Human Genome Project was completed in 2003, it revealed that genes comprise a tiny minority. About 98 percent of the genome is somethi... Read more →
    Could “genome” be a misnomer? The name implies that our genetic information is mainly genes, yet when the Human Genome Project was completed in 2003, it revealed that genes comprise a tiny minority. About 98 percent of the genome is somethi... Read more →

  • 0 – Molecules and a Mission
    0 – Molecules and a Mission
    Play
    Published: 27 Jan 2017 Duration: 03:08
    We are Base Pairs, the podcast about "the power of genetic information." But why did we choose this name? In this bonus episode, we explain the molecules and the metaphor. Pictured: Tin model of Adenine as first constructed by James Watson ... Read more →
    We are Base Pairs, the podcast about "the power of genetic information." But why did we choose this name? In this bonus episode, we explain the molecules and the metaphor. Pictured: Tin model of Adenine as first constructed by James Watson ... Read more →

  • 7 – The Brain Atlas
    7 – The Brain Atlas
    Play
    Published: 14 Dec 2016 Duration: 26:05
    One in six people suffers from a mental disorder, and yet, compared to cancer and infectious disease, neuropsychiatric treatment options have barely improved since the 1950s. But why is that? In this episode of Base Pairs, we explore some o... Read more →
    One in six people suffers from a mental disorder, and yet, compared to cancer and infectious disease, neuropsychiatric treatment options have barely improved since the 1950s. But why is that? In this episode of Base Pairs, we explore some o... Read more →

  • 6 - When Antioxidants are Pro-cancer
    6 - When Antioxidants are Pro-cancer
    Play
    Published: 14 Nov 2016 Duration: 22:05
    Fighting cancer is so difficult in part because the healthy cells we want to support often end up casualties in the crossfire of toxic treatments. This episode is about how we might overcome this obstacle even in some of the most difficult ... Read more →
    Fighting cancer is so difficult in part because the healthy cells we want to support often end up casualties in the crossfire of toxic treatments. This episode is about how we might overcome this obstacle even in some of the most difficult ... Read more →

  • 5 - Sink or Swim
    5 - Sink or Swim
    Play
    Published: 14 Oct 2016 Duration: 22:14
    Professor Adrian Krainer was offered the opportunity to run his own lab when he was just 27 years old as part of a brand new “Fellows” program—which allowed him, in his words, to “sink or swim.” These kinds of programs are rare, as investin... Read more →
    Professor Adrian Krainer was offered the opportunity to run his own lab when he was just 27 years old as part of a brand new “Fellows” program—which allowed him, in his words, to “sink or swim.” These kinds of programs are rare, as investin... Read more →

  • 4 - The People Problem
    4 - The People Problem
    Play
    Published: 15 Sep 2016 Duration: 21:44
    Nearly ten billion people will walk the Earth by 2050, and for some of the poorest and fastest growing countries, that could mean a bleak and hungry future. Dr Josef Schmidhuber of the FAO and CSHL Professor David Jackson explain what has g... Read more →
    Nearly ten billion people will walk the Earth by 2050, and for some of the poorest and fastest growing countries, that could mean a bleak and hungry future. Dr Josef Schmidhuber of the FAO and CSHL Professor David Jackson explain what has g... Read more →

  • 3 - Non-modern Family
    3 - Non-modern Family
    Play
    Published: 15 Aug 2016 Duration: 17:35
    From the scale of a single ancient murder victim to interactions between large groups of humans and Neanderthals who lived 100,000 years ago, genetic information holds many secrets about human history. In this episode, "Ötzi the Iceman" and... Read more →
    From the scale of a single ancient murder victim to interactions between large groups of humans and Neanderthals who lived 100,000 years ago, genetic information holds many secrets about human history. In this episode, "Ötzi the Iceman" and... Read more →

  • 2 - Corn Controversy
    2 - Corn Controversy
    Play
    Published: 15 Jul 2016 Duration: 19:22
    The ongoing GMO labeling debate wasn't the first agricultural controversy. In the early 1900s, it was a new and so-called "wicked" breeding technique that had everyone on edge. In this episode of Base Pairs, we dive into the surprisingly co... Read more →
    The ongoing GMO labeling debate wasn't the first agricultural controversy. In the early 1900s, it was a new and so-called "wicked" breeding technique that had everyone on edge. In this episode of Base Pairs, we dive into the surprisingly co... Read more →

  • 1 - From Phages to Faces
    1 - From Phages to Faces
    Play
    Published: 8 Jun 2016 Duration: 22:54
    Cold Spring Harbor Laboratory's first fully-produced podcast series! Base Pairs ​tells​ stories that ​convey​ the power of genetic information — past and present. This pilot episode exemplifies the series, offering one story about the quir... Read more →
    Cold Spring Harbor Laboratory's first fully-produced podcast series! Base Pairs ​tells​ stories that ​convey​ the power of genetic information — past and present. This pilot episode exemplifies the series, offering one story about the quir... Read more →

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